If you mean the work profile:
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The VPN does not apply to the work profile, i think the app that creates it needs to define a proxy or VPN, otherwise it’s a direct connection.
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I think you can’t easily set up a VPN in the work profile, but I never tried it. If you used Instagram with a VPN up until this point, it might be good to continue using it. If you didn’t, don’t start now if you will stop using Instagram soon anyway.
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You can “mount”/give permission to read specific folders of the main or work profile on the other one. It’s read-only. For example WhatsApp has an option to switch the image selection to the main profile when sending an image.
The advantage of FreeTube is that if it doesn’t work, it can use an Invidious instance as a fallback.